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KMID : 0351619710120010115
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Kyungpook Medical Journal
1971 Volume.12 No. 1 p.115 ~ p.123
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Studies on Parasitemia and Osmotic Fragility of Erythrocytes in Malaria Patients
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Abstract
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This study was attempted to elucidate the possible changes of RBC osmotic fragility on various levels of trophozoidal densities in falciparum malaria patients from the control.
A serial study of RBC osmotic fragility was made in 21 falciparum malaria patients who were classified into 4 groups accordiag to the levels of malaria parasite density.
Also, an evaluation was made for malarial endemicity and the threshold value of malaria parasitemia to evoke malarial symptoms in 101 malaria patients.
Results obtained are summarized as follows :
1. The mean value of parasite density in malaria patients was 20,447/mm³, blood.
2. The mean values of parasite densities in falciparum and vivax malaria were 21,742/mm³, blood, and 13,020/mm³, blood respectively.
3. The density to evoke malarial symptoms in terms of the 50 percent cumulative frequency in malaria parasitemia was atout 25,000/mm³, blood.
4. In the case where the range of parasite density was between 12801 to 25600/mm³, blood, RBC osmotic fragility was significantly increased especially in 0.45-0.50% NaCl solution, comparing with the normal.
5. In parasite density of 25601∼51200/mm³, blood, RBC osmotic fragility in 0.45% NaCl solution was prominently increased, while in 0.50% NaCl solution, it was not prominent.
6. Although RBC osmotic fragility was found to be definitely increased in malaria parasitemia comparing with the normal, the increase of osmotic fragility was not proportional to that of the parasite density.
Therefore, the influence of mechanical fragility and disuniformity of time in sampling blood should be put into consideration in analysing the results obtained in this study.
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KEYWORD
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